The trip I take, and recommend to others, is described on the page of
DRIVING DIRECTIONS at the TouringSFO site at http://geocities.com/touringsfo/
and further detailed in the report "A Trip to Anaheim..." inked to it.

As Hatunen pointed out, you won't be near the PCH until you get to
Oxnard, about 330 miles from San Francisco's City Hall, beyond Santa
Barbara.